Liesel Deppe was born in South Africa and received her undergraduate degree from the University of KwaZulu-Natal. A scholarship from the German Academic Exchange Service enabled her to further her studies at the Hochschule für Musik und Theater in Munich, Germany, where she obtained a Meisterklassendiplom. She spent one year with Alexa Still at the University of Colorado in Boulder, before moving to Canada where she obtained her M.Mus. degree from the University of Western Ontario. Liesel Deppe obtained the degree of Doctor of Musical Arts in November 2011 from the University of Toronto where she studied with Leslie Newman.
She has played with various ensembles and orchestras in South Africa, Europe, the United States and Canada. In the USA she was a member of the Central City Opera Company and the Fort Collins Symphony Orchestra, while also playing as a substitute with the Colorado Springs Orchestra. In 2002 and 2003 she was a member of the National Academy Orchestra, with whom she also performed as a soloist. During the 2006-2007 season she was awarded a grant from the Canada Council for the Arts, which enabled her to study with various flutists in the United Kingdom and Europe. Liesel is a member of the Windsor Symphony Orchestra and a substitute musician with both the Hamilton Philharmonic Orchestra and the Kitchener-Waterloo Symphony. She has been teaching the University of Windsor since 2015 while also managing bookkeeping and ticketing for London Symphonia.